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Levodopa/Carbidopa - Interactions and Warnings

Concurrent ingestion of iron causes marked decreases in the bioavailability of a number of drugs including levodopa and carbidopa. The major mechanism of these drug interactions is the formation of iron-drug complexes (chelation or binding of iron by the involved drug).
- Br J Clin Pharmacol 1991 Mar;31(3):251-5 -- Iron supplements: a common cause of drug interactions. -- Campbell NR, Hasinoff BB.

Adverse interaction of levodopa with tricyclic antidepressants.
- Practitioner 1982 Aug;226(1370):1447-9 -- Adverse interaction of levodopa with tricyclic antidepressants. -- Edwards M.

Drug interactions between levodopa, tranylcypromine, and carbidopa have been studied in 4 patients with idiopathic parkinsonism. Pressor responses were induced by a combination of levodopa and tranylcypromine. These hypertensive reactions were inhibited by carbidopa, indicating that they are mediated at the periphery. Very small doses of levodopa induced an improvement in parkinsonism when patients were concomitantly taking carbidopa and tranylcypromine, but adverse reactions were prominent.
- Clin Pharmacol Ther 1975 Sep;18(3):273-7 -- Interactions of levodopa with inhibitors of monoamine oxidase and L-aromatic amino acid decarboxylase. -- Teychenne PF, Calne DB, Lewis PJ, Findley LJ.

Many herbs and supplements can interact with this medication. Consult with your physician before using them.

last update: November 2008

This information is not intended to be a substitute for professional medical advice. You should not use this material to diagnose or treat a health condition or disease without consulting with your healthcare provider.
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