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Bromelain Side Effects, Interactions and Warnings

  • May potentially increase the risk of bleeding or potentiate the effects of warfarin therapy.
    - Am J Health Syst Pharm 2000 Jul 1;57(13):1221-7; quiz 1228-30 -- Potential interactions between alternative therapies and warfarin. -- Heck AM, DeWitt BA, Lukes AL.

  • Caution is advised if administering bromelain to individuals with hypertension, since one report indicated individuals with pre-existing hypertension might experience tachycardia following high doses of bromelain.
    - Gutfreund A, Taussig S, Morris A. Effect of oral bromelain on blood pressure and heart rate of hypertensive patients. Hawaii Med J 1978;37:143-146.

  • The allergenic potential of proteolytic enzymes should not be underestimated. They can cause IgE-mediated respiratory allergies of both the immediate type and the late-phase of immediate type. Bromelain, due to its use as a meat tenderizer and to clarify beer, is considered a potential ingestive allergen.
    - Gailhofer G, Wilders-Truschnig M, Smolle J, Ludvan M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18:445-450.

  • Avoid if allergic to pineapple. Can increase the effect of blood-thinning drugs. Large doses can cause upset stomach and cramps.

  • Bromelain may interact with antibiotics.
    - Br J Clin Pharmacol 1978 Dec;6(6):552-4 -- The effect of bromelain on the absorption of orally administered tetracycline. -- Bradbrook ID, Morrison PJ, Rogers HJ.

last update: March 2014

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