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Cayenne Side Effects, Interactions and Warnings

  • Cayenne may increase the risk of bleeding or potentiate the effects of warfarin therapy.
    - Am J Health Syst Pharm 2000 Jul 1;57(13):1221-7; quiz 1228-30 -- Potential interactions between alternative therapies and warfarin. -- Heck AM, DeWitt BA, Lukes AL. -- School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, IN, USA.

  • Loss of enamel and a deep black stain of the teeth in a 40-year-old diabetic patient are strongly suggested to be caused by the daily consumption of a cheap white wine and, possibly, by the chewing of cayenne. The wine proved to be rather acid, thereby promoting abrasion as a result of gnashing, and to contain a high concentration of tannin.
    - Oral Surg Oral Med Oral Pathol 1987 Oct;64(4):427-31 -- An unusual case of black teeth. -- Schuurs AH, Abraham-Inpijn L, van Straalen JP, Sastrowijoto SH.

  • Around one third of patients experienced local adverse events with capsaicin as a topical treatment for pain.
    - BMJ. 2004 Apr 24;328(7446):991. Epub 2004 Mar 19. -- Systematic review of topical capsaicin for the treatment of chronic pain. -- Mason L, Moore RA, Derry S, Edwards JE, McQuay HJ.

  • Cayenne was responsible for skin reactions.
    -Allergy 1981 Oct;36(7):487-93 -- Immediate skin test reactions to spices. -- Niinimaki A, Hannuksela M.

  • Cayenne can increase the amount of absorption rate of other herbs and prescription medications due to its' heating properties.

  • Results show that Capsicum ingestion reduces oral drug bioavailability, likely as a result of the gastrointestinal effects of capsaicin.
    - Can J Physiol Pharmacol 1999 Jun;77(6):441-6 -- Ingestion of chilli pepper (Capsicum annuum) reduces salicylate bioavailability after oral asprin administration in the rat. -- Cruz L, Castaneda-Hernandez G, Navarrete A.

  • Inhibitory effect of capsaicin on intestinal glucose absorption in vitro.
    - Food Cosmet Toxicol 1978 Oct;16(5):469-73 -- Inhibitory effect of capsaicin on intestinal glucose absorption in vitro. -- Monsereenusorn Y, Glinsukon T.

  • It was found that a single dose of Capsicum fruit could affect pharmacokinetic parameters of theophylline, while a repeated dose affected the metabolic pathway of xanthine oxidase.
    - Eur J Drug Metab Pharmacokinet 1995 Jul-Sep;20(3):173-8 -- Theophylline pharmacokinetics and metabolism in rabbits following single and repeated administration of Capsicum fruit. -- Bouraoui A, Brazier JL, Zouaghi H, Rousseau M.

  • Use extreme caution around children when using cayenne and capsaicin products. Recommendations have been found on the internet to use cayenne as a deterrent to thumb sucking -- please do not follow those questionable instructions.

last update: March 2014

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