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Calcium Side Effects, Interactions and Warnings

  • High intake of dietary calcium appears to decrease risk for symptomatic kidney stones, whereas intake of supplemental calcium may increase risk. Because dietary calcium reduces the absorption of oxalate, the apparently different effects caused by the type of calcium may be associated with the timing of calcium ingestion relative to the amount of oxalate consumed. However, other factors present in dairy products (the major source of dietary calcium) could be responsible for the decreased risk seen with dietary calcium.
    - Ann Intern Med 1997 Apr 1;126(7):497-504 -- Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women. -- Curhan GC, Willett WC, Speizer FE, Spiegelman D, Stampfer MJ.

  • The mechanisms causing drug-fortified food interactions are the some well-known mechanisms that cause other drug-mineral interactions. Certain drugs may exhibit decreased absorption due to chelation and adsorption. Other drugs may have decreased absorption or increased excretion due to changes in gastric and/or urinary pH. The results of such interactions may be clinically insignificant or severe, including treatment failure, frequent dose changes, antibiotic resistance, and increased morbidity and mortality.
    - J Clin Pharmacol 2002 Apr;42(4):437-43 -- Is it really OK to take this with food? Old interactions with a new twist. -- Wallace AW, Amsden GW.

  • Use caution when combining calcium with prescription medications. Adverse interactions may occur.

  • Citrate-containing compounds augment absorption of aluminum from food and tap water, causing aluminum accumulation in bone and brain despite normal renal function. Citrate also enhances lead absorption in animals. During calcium citrate therapy, urinary aluminum excretion and plasma aluminum level increased significantly. Treatment with calcium citrate significantly increases absorption of aluminum from dietary sources.
    - South Med J 1994 Sep;87(9):894-8 -- Aluminum and lead absorption from dietary sources in women ingesting calcium citrate. -- Nolan CR, DeGoes JJ, Alfrey AC.

Nutrient Values
Fruits Vegetables Fish and Seafood Meat and Poultry Nuts

  • Nutrition Information

  • last update: February 2014

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