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Zinc Side Effects, Interactions and Warnings

  • Paper reviews possible hazards associated with high intake of folic acid in the general population. Among the potential safety issues are interaction between folic acid and zinc.
    - Schweiz Rundsch Med Prax 2002 Jan 9;91(1-2):7-16 -- Safety aspects of folic acid for the general population -- Eichholzer M, Luthy J, Moser U, Stahelin HB, Gutzwiller F.

  • Copper deficiency was found in an adult patient who had received excessive daily oral zinc for 10 mo. The deficiency was characterized by hypochromic-microcytic anemia, leukopenia, and neutropenia. These data suggest that the elimination of excess zinc is slow and that, until such elimination occurs, the intestinal absorption of copper is blocked.
    - Gastroenterology 1988 Feb;94(2):508-12 -- Zinc-induced copper deficiency. -- Hoffman HN 2nd, Phyliky RL, Fleming CR.

  • Zinc overuse or overdose may cause paleness, orthostatic pulse changes or heart murmur, anemia and neutropenia. Toxicity can also cause a deficiency in copper levels.
    - Mayo Clin Proc 2002 Jul;77(7):713-6 -- Toxic effects associated with consumption of zinc. -- Igic PG, Lee E, Harper W, Roach KW.

  • Possible interaction between dietary iron and zinc.
    - Biol Trace Elem Res 2002 Aug;88(2):165-83 -- Response of liver and heart trace elements in rats to the interaction between dietary zinc and iron. -- Zaslavsky B, Uthus EO.

  • Use caution before using medications with supplements as absorption levels may be affected.

Nutrient Values
Fruits Vegetables Fish and Seafood Meat and Poultry Nuts

  • Nutrition Information

  • last update: February 2014

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