Colchicine- Interactions and Warnings

– Interactions and Warnings

Colchicine may interfere with the absorption of vitamin B12.
– N Engl J Med 1968 Oct 17;279(16):845-50 — Mechanism of vitamin B12 malabsorption in patients receiving colchicine. — Webb DI, Chodos RB, Mahar CQ, Faloon WW.

The data suggest that colchicine pretreatment leads to significant inhibition of hepatobiliary excretion in CCl4 treated rats. Serum alanine transaminase and aspartate transaminase levels were elevated significantly after the colchicine + CCl4 combination, indicating hepatic injury.
– Biochem Pharmacol 1991 Nov 27;42(12):2323-32 — Effect of colchicine on hepatobiliary function in CCl4 treated rats. — Rao CV, Mehendale HM.

last update: November 2008

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