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Brand Name: Comtan®
Active Ingredient:   entacapone
Strength(s): 200mg
Dosage Form(s):   Tablets
Company Name:    Orion Corporation
Prescription only
*Date Approved by FDA:   October 19, 2022
*Approval by FDA does not mean that the drug is
available for consumers at this time.

What is Comtan used for?

Comtan is used together with carbidopa/
levodopa to treat people with Parkinson’s disease that experience the signs and
symptoms of end-of-dose "wearing-off".

Comtan’s effectiveness has not been proven in people with Parkinson’s
disease that do not experience end-of-dose "wearing-off".

General Precautions:

  • Comtan should be used with caution in patients with liver problems.
  • Do not stop taking Comtan without first discussing it with your doctor.
  • Do not drive a car or operate heavy machinery until you know how you will react
    to Comtan.
  • Be especially careful when taking other sleep-inducing drugs while using Comtan

What should I tell my doctor or health care provider?

  • Because certain other medications can interact with Comtan, review all
    medications that you are taking with your health care provider, including those that you
    take without a prescription.
  • Check with your health care provider to make sure that you are not taking certain
    types of monoamine oxidase (MAO) inhibitors.
  • Tell your health care provider if you are trying to become pregnant, are
    pregnant, or are breast-feeding.

What are some possible side effects of Comtan? (This is NOT
a complete list of side effects reported with Comtan. Your health care provider can
discuss with you a more complete list of side effects.

Some of the side effects listed below may not appear for up to twelve weeks.

  • Abnormal jerky movements
  • Nausea
  • Discolored (brownish orange) urine
  • Diarrhea
  • Abdominal pain
  • Dizziness or fainting especially upon quickly standing or going from a laying
    down to an upright position
  • Confusion
  • Sweating

Individuals treated with Comtan should tell their health care provider right
away if they develop any of the following symptoms:

  • Severe diarrhea
  • Hallucinations
  • Muscle pain or prolonged rigidity
  • High fever

For more detailed information about Comtan, ask your health care provider.   Link
to Comtan’s approved label   

Date Posted: 6/7/00

Revised: 11/16/00

Back to Drug Side Effects

source: FDA

last update: December 2004

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