Copper was the most proinflammatory metal; responses suggest that metals induce pulmonary inflammation by differing pathways or combinations of signals.
– Toxicol Appl Pharmacol 2001 Nov 15;177(1):46-53 — Differential ability of transition metals to induce pulmonary inflammation. — Rice TM, Clarke RW, Godleski JJ, Al-Mutairi E, Jiang NF, Hauser R, Paulauskis JD.
Nausea and vomiting occurs after ingestion of drinking water with high copper content.
– Regul Toxicol Pharmacol 2001 Jun;33(3):271-5 — Nausea threshold in apparently healthy individuals who drink fluids containing graded concentrations of copper.
While elevated serum copper concentration was found in users of all types of oral contraceptives, elevation was more pronounced among women taking oral contraceptives with antiandrogen effective progestins like antiandrogens or third generation oral contraceptives containing desogestrel. Further investigation is required to shed light on the possible role of high serum copper concentration in increasing cardiovascular or thrombotic risk of women using oral contraceptives.
– Eur J Clin Nutr 1998 Oct;52(10):711-5 — Effect of oral contraceptive progestins on serum copper concentration. — Berg G, Kohlmeier L, Brenner H.
Copper deficiency was found in an adult patient who had received excessive daily oral zinc for 10 mo. The deficiency was characterized by hypochromic-microcytic anemia, leukopenia, and neutropenia. These data suggest that the elimination of excess zinc is slow and that, until such elimination occurs, the intestinal absorption of copper is blocked.
– Gastroenterology 1988 Feb;94(2):508-12 — Zinc-induced copper deficiency. — Hoffman HN 2nd, Phyliky RL, Fleming CR.
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