Fenugreek may increase the risk of bleeding or potentiate the effects of warfarin therapy.

– Am J Health Syst Pharm 2000 Jul 1;57(13):1221-7; quiz 1228-30 —
Potential interactions between alternative therapies and warfarin. — Heck AM, DeWitt BA, Lukes AL. — School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, IN, USA.

Two cases of severe allergy to fenugreek. Report on two cases of immediate allergy following ingestion, inhalation, and external application of fenugreek seed powder. In the first case, inhalation of the fenugreek seed powder resulted in rhinorrhea, wheezing, and fainting. The second case was of a patient with chronic asthma who developed numbness of head, facial angioedema, and wheezing after application of fenugreek paste to her scalp as a treatment for dandruff.
– Ann Allergy Asthma Immunol 1997 Mar;78(3):297-300 — Allergy to fenugreek (Trigonella foenum graecum). — Patil SP, Niphadkar PV, Bapat MM.

Results suggest that the aqueous extract of Trigonella foenum-graecum leaves given both orally and intraperitoneally possesses a hypoglycaemic effect in normoglycaemic and alloxan induced hyperglycaemic rats.
– J Ethnopharmacol 1997 Nov;58(3):149-55 — Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. — Abdel-Barry JA, Abdel-Hassan IA, Al-Hakiem MH.

– Not recommended if you are pregnant. Can cause uterine contractions.

Diabetic mothers should use caution with fenugreek since it can cause lowering of blood glucose levels.