Use caution if you have depression or bipolar disorder and are taking or considering taking inositol. There is a possibility that manic episodes may occur.
– Levine J, Witztum E, Greenberg BD, et al. — Inositol-induced mania?. — Am J Psychiatry. 1996;153:839.
Inositol interacted with lithium when rearing behavior was measured. More specific interactions were found between lithium and inositol following cholinergic and serotonergic stimulation. Inositol attenuated lithium-pilocarpine seizures and the enhancement of the serotonin syndrome.
– Eur Neuropsychopharmacol 1999 Sep;9(5):385-97 — Interactions of lithium and drugs that affect signal transduction on behaviour in rats. — Kofman O, Patishi Y.
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