May cause irritation of mucous membranes (throat, intestines).

May interfere with absorption of simultaneously administered drugs.

Do not take large doses for long periods of time.

Sarsaparilla may cause kidney or stomach irritation and should not be used if you are pregnant or breastfeeding. – Blumenthal M, Busse WR, Goldberg A. — Integrative Medicine Communications, 1998, 372–3. — The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines.