Trimethoprim/Sulfamethoxazole- Interactions and Warnings

– Interactions and Warnings

Several cases of pyloric stenosis have occurred in infants treated with erythromycin during the first weeks of life. A disturbing report of a cluster of cases is enough to avoid erythromycin use in neonates.
– Prescrire Int 2001 Feb;10(51):16 — Erythromycin-induced pyloric stenosis in infants.

Potassium levels in the body may be increased by trimethoprim-sulfamethoxazole.
– Am J Nephrol 1999;19(3):389-94 — Trimethoprim-sulfamethoxazole therapy in outpatients: is hyperkalemia a significant problem? — Alappan R, Buller GK, Perazella MA.

Folate metabolism may be adversely affected by trimethoprim.
– Clin Pharmacol Ther 1968 Sep-Oct;9(5):550-60 — Effects of trimethoprim on folate metabolism in man. — Kahn SB, Fein SA, Brodsky I.

Please see: Antibiotics

last update: November 2008

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