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Valerian and lorazepam may cause an adverse interaction.
– Drugs Aging 2002;19(11):879-86 — Potential Interactions between Herbal Medicines and Conventional Drug Therapies Used by Older Adults Attending a Memory Clinic. — Dergal JM, Gold JL, Laxer DA, Lee MS, Binns MA, Lanctot KL, Freedman M, Rochon PA.
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Valerian may potentiate the effects of antiepileptic medications, increasing their sedative and cognitive effects.
– 2001 Dec;2(6):524-532 — Herbal Medicines and Epilepsy: The Potential for Benefit and Adverse Effects. — Spinella M.
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Valerian should not be used concomitantly with barbiturates because excessive sedation may occur.
– Arch Intern Med 1998 Nov 9;158(20):2200-11 — Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. — Miller LG.
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The findings in this study suggest adverse interactions between haloperidol and valerian are possible when taken together.
– Potentially adverse interactions between haloperidol and valerian. — Dalla Corte CL, Fachinetto R, Colle D, Pereira RP, Avila DS, Villarinho JG, Wagner C, Pereira ME, Nogueira CW, Soares FA, Rocha JB. — Food Chem Toxicol. 2008 Jul;46(7):2369-75. Epub 2008 Mar 28.
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May produce sensations of “strangeness” in some individuals. These persons should not use valerian.
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In extremely high doses, valerian may cause paralysis and weakening of the heartbeat. Do not exceed the recommended dose.
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The concomitant use of opioid analgesics with the sedative herbal supplements, valerian, kava and chamomile, may lead to increased central nervous system (CNS) depression.
– J Clin Pharm Ther 2002 Dec;27(6):391-401 — Herbal medication: potential for adverse interactions with analgesic drugs. — Abebe W.
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A study reports people experiencing hypotension and tachycardia after a mix containing chamomile, valerian and melissa.
– Phytother Res. 2009 Jan 12. — Attitudes and knowledge toward natural products safety in the pharmacy setting: an Italian study.Cuzzolin L, Benoni G.
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The findings suggest adverse interactions between haloperidol and valerian. When administered concomitantly they provoked an inhibition of hepatic delta-ALA-D activity. The delta-ALA-D reactivation index was higher in rats treated with HP plus valerian than other treated groups.
– Food Chem Toxicol. 2008 Jul;46(7):2369-75. — Potentially adverse interactions between haloperidol and valerian.Dalla Corte CL, Fachinetto R, Colle D, Pereira RP, Avila DS, Villarinho JG, Wagner C, Pereira ME, Nogueira CW, Soares FA, Rocha JB.
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